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Article

Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.

American journal of physiology. Renal physiology - 1 Oct 2010

Shima James E, Komori Takafumi, Taylor Travis R, Stryke Doug, Kawamoto Michiko, Johns Susan J, Carlson Elaine J, Ferrin Thomas E, Giacomini Kathleen M

Abstract excerpt

Apical reabsorption from the urine has been shown to be important for such processes as the maintenance of critical metabolites in the blood and the excretion of nephrotoxic compounds. The solute carrier (SLC) transporter OAT4 (SLC22A11) is expressed on the apical membrane of renal proximal tubule cells and is known to mediate the transport of a variety of xenobiotic and endogenous organic anions. Functional...

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Identifiers

PMID: 20668102
DOI: 10.1152/ajprenal.00312.2010
PMCID: PMC2957254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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