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Article

Type 1 sodium-dependent phosphate transporter acts as a membrane potential-driven urate exporter.

Current molecular pharmacology - 1 Jul 2013

Miyaji Takaaki, Kawasaki Tatsuya, Togawa Natsuko, Omote Hiroshi, Moriyama Yoshinori

Abstract excerpt

SLC17A1 protein (NPT1) was the first identified member of the SLC17 phosphate transporter family, and is known to mediate Na(+)/inorganic phosphate (Pi) co-transport when expressed in Xenopus oocytes. Although this protein was suggested to be a renal polyspecific anion exporter, its transport properties were not well characterized. The clean biochemical approach revealed that proteoliposomes comprising purified...

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Identifiers

PMID: 23876149
DOI: 10.2174/18744672113069990035

Genes

PAH

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