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Article

Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4).

British journal of pharmacology - 1 Jan 2010

Zhou Fanfan, Zhu Ling, Cui Pei H, Church W Bret, Murray Michael

Abstract excerpt

BACKGROUND AND PURPOSE: The human organic anion transporter (hOAT) family of transmembrane carrier proteins mediate the cellular flux of anionic substances, including certain hormones and anti-cancer drugs. hOAT4 is highly expressed at the apical membrane of the renal tubular cell and facilitates drug re-absorption in the kidney. In the present study, the impact of 10 nonsynonymous single nucleotide polymorphisms...

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Identifiers

PMID: 20015291
DOI: 10.1111/j.1476-5381.2009.00545.x
PMCID: PMC2825363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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