Article
Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3).
Journal of human genetics - 1 Jan 2006
Bhatnagar Vibha, Xu Gang, Hamilton Bruce A, Truong David M, Eraly Satish A, Wu Wei, Nigam Sanjay K
Abstract excerpt
Kidney excretion of numerous organic anionic drugs and endogenous metabolites is carried out by a family of multispecific organic anion transporters (OATs). Two closely related transporters, SLC22A6, initially identified by us as NKT and also known as OAT1, and SLC22A8, also known as OAT3 and ROCT, are thought to mediate the initial steps in the transport of organic anionic drugs between the blood and proximal...
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