Article
Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.
The Journal of biological chemistry - 5 Nov 2010
Jutabha Promsuk, Anzai Naohiko, Kitamura Kenichiro, Taniguchi Atsuo, Kaneko Shuji, Yan Kunimasa, Yamada Hideomi, Shimada Hidetaka, Kimura Toru, Katada Tomohisa, Fukutomi Toshiyuki, Tomita Kimio, Urano Wako, Yamanaka Hisashi, Seki George, Fujita Toshiro, Moriyama Yoshinori, Yamada Akira, Uchida Shunya, Wempe Michael F, Endou Hitoshi, Sakurai Hiroyuki
Abstract excerpt
The evolutionary loss of hepatic urate oxidase (uricase) has resulted in humans with elevated serum uric acid (urate). Uricase loss may have been beneficial to early primate survival. However, an elevated serum urate has predisposed man to hyperuricemia, a metabolic disturbance leading to gout, hypertension, and various cardiovascular diseases. Human serum urate levels are largely determined by urate reabsorption...
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