NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.

doi:10.1002/art.38884

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NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2015

Chiba Toshinori, Matsuo Hirotaka, Kawamura Yusuke, Nagamori Shushi, Nishiyama Takashi, Wei Ling, Nakayama Akiyoshi, Nakamura Takahiro, Sakiyama Masayuki, Takada Tappei, Taketani Yutaka, Suma Shino, Naito Mariko, Oda Takashi, Kumagai Hiroo, Moriyama Yoshinori, Ichida Kimiyoshi, Shimizu Toru, Kanai Yoshikatsu, Shinomiya Nariyoshi

Abstract excerpt

OBJECTIVE: Serum uric acid (SUA) levels in humans are mainly regulated by urate transporters. Recent genome-wide association studies suggested that common variants of the human sodium-dependent phosphate cotransporter type 1 gene (NPT1/SLC17A1) influence SUA. NPT1 has been reported to mediate urate transport, but its physiologic role in regulating SUA in humans remains unclear. Furthermore, the findings of...

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PMID: 25252215
DOI: 10.1002/art.38884

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