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Article

CAF-I-dependent control of degradation of the discontinuous strands during mismatch repair

31 Jan 2011

Abstract excerpt

DNA mismatch repair (MMR) is a multifunctional process that promotes genetic stability and suppresses carcinogenesis. Correction of DNA replication errors is its major function. Despite the importance of MMR, its functioning in eukaryotes is not well understood. Here we report that human mismatch correction reactions in cell-free extracts occur during concomitant nick-dependent nucleosome assembly shaped by the...

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PMID: 21282622
DOI: 10.1073/pnas.1015914108

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