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Interplay between mismatch repair and chromatin assembly

9 Jan 2012

Abstract excerpt

Single strand nicks and gaps in DNA have been reported to increase the efficiency of nucleosome loading mediated by chromatin assembly factor 1 (CAF-1). However, on mismatch-containing substrates, these strand discontinuities are utilized by the mismatch repair (MMR) system as loading sites for exonuclease 1, at which degradation of the error-containing strand commences. Because packaging of DNA into chromatin...

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PMID: 22232658
DOI: 10.1073/pnas.1106696109

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