Article

The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repair

2024-06-13

Abstract excerpt

<h4>ABSTRACT</h4> In eukaryotic post-replicative mismatch repair, MutS homologs (MSH) detect mismatches and recruit MLH complexes to nick the newly replicated DNA strand upon activation by the replication processivity clamp, PCNA. This incision enables mismatch removal and DNA repair. Biasing MLH endonuclease activity to the newly replicated DNA strand is crucial for repair. In reconstituted in vitro assays, PCN...

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Literature Corpus work: 1733bb28-38f0-5212-86b7-71fbaf5f8f06
DOI: 10.1101/2024.06.13.598860

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