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Article

Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMM.

The American journal of pathology - 1 Feb 2011

Silverman-Gavrila Rosalind, Silverman-Gavrila Lorelei, Hou Guangpei, Zhang Ming, Charlton Milton, Bendeck Michelle P

Abstract excerpt

Directed migration of smooth muscle cells (SMCs) from the media to the intima in arteries occurs during atherosclerotic plaque formation and during restenosis after angioplasty or stent application. The polarized orientation of the microtubule-organizing center (MTOC) is a key determinant of this process, and we therefore investigated factors that regulate MTOC polarity in vascular SMCs. SMCs migrating in vivo...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21281821
DOI: 10.1016/j.ajpath.2010.10.001
PMCID: PMC3128507

Genes

ARPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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