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Article

Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase.

Cardiovascular research - 1 Dec 2016

Hsiao Sarah T, Spencer Tim, Boldock Luke, Prosseda Svenja Dannewitz, Xanthis Ioannis, Tovar-Lopez Francesco J, Van Beusekom Heleen M M, Khamis Ramzi Y, Foin Nicolas, Bowden Neil, Hussain Adil, Rothman Alex, Ridger Victoria, Halliday Ian, Perrault Cecile, Gunn Julian, Evans Paul C

Abstract excerpt

AIMS: Stent deployment causes endothelial cells (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow perturbation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration, we identified an...

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Identifiers

PMID: 27671802
DOI: 10.1093/cvr/cvw210
PMCID: PMC5157135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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