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Article

5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.

Annals of neurology - 1 Jan 2011

Chu Jin, Praticò Domenico

Abstract excerpt

OBJECTIVE: The 5-lipoxygenase (5-LO) enzymatic pathway is widely distributed within the central nervous system, and is upregulated in Alzheimer's disease. However, the mechanism whereby it may influence the disease pathogenesis remains elusive. METHODS: We evaluated the molecular mechanism by which 5-LO regulates amyloid β (Aβ) formation in vitro and in vivo by pharmacological and genetic approaches. RESULTS:...

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Identifiers

PMID: 21280074
DOI: 10.1002/ana.22234
PMCID: PMC3051361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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