Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.

Molecular psychiatry - 1 Nov 2015

Chu J, Li J-G, Giannopoulos P F, Blass B E, Childers W, Abou-Gharbia M, Praticò D

Abstract excerpt

The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the present paper, we studied the effect of its pharmacologic inhibition on the AD-like phenotype of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 12-Lipoxygenase
Share to Arachidonate 15-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Psychological

Share to Fluorenes

Share to Maze Learning

Share to Memory Disorders

Share to Neuroblastoma

Source

Identifiers

PMID: 25560760
DOI: 10.1038/mp.2014.170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.PMID 25560760Read ↗

A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism.Semantic proximity Read ↗

Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.Semantic proximity Read ↗

Amelioration of the Alzheimer's Disease Phenotype by Absence of 12/15-LipoxygenaseSemantic proximity Read ↗

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.Semantic proximity Read ↗

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimerâ€™s disease phenotypeSemantic proximity Read ↗

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.Semantic proximity Read ↗

Neurodegenerative disease associated pathways in brain of the triple transgenic Alzheimer’s model are reversed in vivo following two weeks peripheral administration of fasudilSemantic proximity Read ↗

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.Semantic proximity Read ↗

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.Semantic proximity Read ↗

Prostaglandin D2 pathway in a transgenic rat model of Alzheimer’s disease: therapeutic potential of timapiprant a DP2 antagonistSemantic proximity Read ↗

L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.