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Article

Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Jun 2009

Puzzo Daniela, Staniszewski Agnieszka, Deng Shi Xian, Privitera Lucia, Leznik Elena, Liu Shumin, Zhang Hong, Feng Yan, Palmeri Agostino, Landry Donald W, Arancio Ottavio

Abstract excerpt

Memory loss, synaptic dysfunction, and accumulation of amyloid beta-peptides (A beta) are major hallmarks of Alzheimer's disease (AD). Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation. Here, we report that the phosphodiesterase 5 inhibitor (PDE5) sildenafil (Viagra), a...

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Identifiers

PMID: 19553447
DOI: 10.1523/JNEUROSCI.0864-09.2009
PMCID: PMC6666028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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