Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.

Molecular neurodegeneration - 5 Jan 2012

Chu Jin, Giannopoulos Phillip F, Ceballos-Diaz Carolina, Golde Todd E, Pratico Domenico

Abstract excerpt

BACKGROUND: The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic absence results in a reduction of Amyloid beta (Aβ) levels in the Tg2576 mice.Here by employing an adeno-associated viral (AAV) vector system to over-express 5LO in the same mouse model, we examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Arachidonate 5-Lipoxygenase

Share to Dependovirus

Share to Genetic Vectors

Share to Memory

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 22222029
DOI: 10.1186/1750-1326-7-1
PMCID: PMC3277480

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.PMID 22222029Read ↗

5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.Semantic proximity Read ↗

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimerâ€™s disease phenotypeSemantic proximity Read ↗

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.Semantic proximity Read ↗

Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.Semantic proximity Read ↗

Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Semantic proximity Read ↗

Kat5 cKO Biological Domain Signatures Align with Human Alzheimer’s DiseaseSemantic proximity Read ↗

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.Semantic proximity Read ↗

Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Neurohormonal signalling pathways and the regulation of Alzheimer beta-amyloid metabolism.Semantic proximity Read ↗

Adenylate kinase 5, a novel genetic risk factor for Alzheimer's disease, regulates microglial inflammatory activation.Semantic proximity Read ↗

Peroxiredoxin 5 Decreases Beta-Amyloid-Mediated Cyclin-Dependent Kinase 5 Activation Through Regulation of Ca2+-Mediated Calpain Activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.