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Article

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.

Journal of neuroinflammation - 14 Jun 2012

Chu Jin, Praticò Domenico

Abstract excerpt

BACKGROUND: The 5-lipoxygenase enzyme is widely distributed within the central nervous system and its activity is regulated by the presence and availability of another protein, called 5-lipoxygenase activating protein. While previous works have shown that 5-lipoxygenase is involved in the pathogenesis of Alzheimer's disease, no data are available on the role that 5-lipoxygenase activating protein plays in...

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Identifiers

PMID: 22697885
DOI: 10.1186/1742-2094-9-127
PMCID: PMC3425138

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