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Article

Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.

Molecular neurobiology - 1 Jul 2018

Giannopoulos Phillip F, Praticò Domenico

Abstract excerpt

Brain accumulation of increasing amount of phosphorylated microtubule associated tau protein is one the major hallmark lesions of Alzheimer's disease (AD) and related tauopathies. Consistent evidence from clinical and animal studies has shown that neuroinflammation characterizes these diseases. The 5-lipoxygenase (5LO) is an enzyme protein whose metabolic products are lipids with potent inflammatory actions....

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PMID: 29128902
DOI: 10.1007/s12035-017-0817-7

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