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Article

Homocysteine modulates 5-lipoxygenase expression level via DNA methylation

29 Nov 2016

Abstract excerpt

Elevated levels of homocysteinemia (Hcy), a risk factor for late-onset Alzheimer's disease (AD), have been associated with changes in cell methylation. Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regulated by methylation. However, whether Hcy activates 5LO enzymatic pathway by influencing the methylation status of its promoter remains unknown. Brains from...

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PMID: 27896923
DOI: 10.1111/acel.12550

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