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Article

Modulation of amyloid-β production by leukotriene B4 via the γ-secretase pathway.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Joshi Yash B, Di Meco Antonio, Praticó Domenico

Abstract excerpt

Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) pathogenesis, and among them, the pro-inflammatory 5-lipoxygenase (5LO) enzyme. While previous work has shown that 5LO modulates the amyloidotic phenotype of AD, the exact metabolic product responsible for this biological action remains unknown. In this study, we challenged neuronal cells with leukotriene B4 (LTB4), a major 5LO product, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24008686
DOI: 10.3233/JAD-131223

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