Article
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.
Nature genetics - 1 Mar 2011
Brest Patrick, Lapaquette Pierre, Souidi Mouloud, Lebrigand Kevin, Cesaro Annabelle, Vouret-Craviari Valérie, Mari Bernard, Barbry Pascal, Mosnier Jean-François, Hébuterne Xavier, Harel-Bellan Annick, Mograbi Baharia, Darfeuille-Michaud Arlette, Hofman Paul
Abstract excerpt
Susceptibility to Crohn's disease, a complex inflammatory disease, is influenced by common variants at many loci. The common exonic synonymous SNP (c.313C>T) in IRGM, found in strong linkage disequilibrium with a deletion polymorphism, has been classified as non-causative because of the absence of an alteration in the IRGM protein sequence or splice sites. Here we show that a family of microRNAs (miRNAs),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.