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Article

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

Nature genetics - 1 Sept 2008

McCarroll Steven A, Huett Alan, Kuballa Petric, Chilewski Shannon D, Landry Aimee, Goyette Philippe, Zody Michael C, Hall Jennifer L, Brant Steven R, Cho Judy H, Duerr Richard H, Silverberg Mark S, Taylor Kent D, Rioux John D, Altshuler David, Daly Mark J, Xavier Ramnik J

Abstract excerpt

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is associated with SNPs around IRGM, but coding-sequence variation has been excluded as a source of this association. We identified a common, 20-kb deletion polymorphism, immediately upstream of...

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Source

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Identifiers

PMID: 19165925
DOI: 10.1038/ng.215
PMCID: PMC2731799

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.PMID 19165925Read ↗

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