Risk predisposition for Crohn disease: a "ménage à trois" combining IRGM allele, miRNA and xenophagy.

doi:10.4161/auto.7.7.15595

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Article

Risk predisposition for Crohn disease: a "ménage à trois" combining IRGM allele, miRNA and xenophagy.

Autophagy - 1 Jul 2011

Brest Patrick, Lapaquette Pierre, Mograbi Baharia, Darfeuille-Michaud Arlette, Hofman Paul

Abstract excerpt

Susceptibility to Crohn disease (CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T). We recently showed that miR-196 is overexpressed in the inflammatory intestinal epithelia of individuals with CD and downregulates the IRGM protective (c.313C) but not the risk-associated (c.313T) allele. Eventually, loss of:...

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PMID: 21508684
DOI: 10.4161/auto.7.7.15595

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IRGM

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