Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

doi:10.1038/ng2061

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Article

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Nature genetics - 1 Jul 2007

Parkes Miles, Barrett Jeffrey C, Prescott Natalie J, Tremelling Mark, Anderson Carl A, Fisher Sheila A, Roberts Roland G, Nimmo Elaine R, Cummings Fraser R, Soars Dianne, Drummond Hazel, Lees Charlie W, Khawaja Saud A, Bagnall Richard, Burke Denis A, Todhunter Catherine E, Ahmad Tariq, Onnie Clive M, McArdle Wendy, Strachan David, Bethel Graeme, Bryan Claire, Lewis Cathryn M, Deloukas Panos, Forbes Alastair, Sanderson Jeremy, Jewell Derek P, Satsangi Jack, Mansfield John C, Cardon Lon, Mathew Christopher G

Abstract excerpt

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autop...

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Identifiers

PMID: 17554261
DOI: 10.1038/ng2061
PMCID: PMC2628541

Genes

IRGM
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17554261-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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