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Article

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.

Cancer research - 1 Feb 2011

Timpson Paul, McGhee Ewan J, Morton Jennifer P, von Kriegsheim Alex, Schwarz Juliane P, Karim Saadia A, Doyle Brendan, Quinn Jean A, Carragher Neil O, Edward Mike, Olson Michael F, Frame Margaret C, Brunton Valerie G, Sansom Owen J, Anderson Kurt I

Abstract excerpt

The ability to observe changes in molecular behavior during cancer cell invasion in vivo remains a major challenge to our understanding of the metastatic process. Here, we demonstrate for the first time, an analysis of RhoA activity at a subcellular level using FLIM-FRET (fluorescence lifetime imaging microscopy-fluorescence resonance energy transfer) imaging in a live animal model of pancreatic cancer. In...

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Identifiers

PMID: 21266354
DOI: 10.1158/0008-5472.CAN-10-2267
PMCID: PMC3033324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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