Article

Aurora kinase A enables collective invasion and metastasis by endowing a leader cell phenotype and stabilizing Eplin-mediated cohesion with follower cells

2026-04-02

Abstract excerpt

The metastatic process initiates with collective cell invasion into surrounding tissues and axillary nodes, and subsequent colonization at a distant site. Previously, we found collective invasion is augmented during the G2 cell cycle phase, facilitated through Aurora kinase A (AURKA)-mediated centrosome polarization in the leader cell. Here, we identify cell cycle-associated gene signatures as overrepresented in a...

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Literature Corpus work: 4b70bbce-e365-5c38-8a5b-4ccc5f49ee89
DOI: 10.64898/2026.03.31.715024

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