Article
Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway-dependent Rho/ROCK signaling.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2025
Guzman Asja, Kawase Tatsuya, Devanny Alexander J, Efe Gizem, Navaridas Raúl, Yu Karen, Regunath Kausik, Mercer Iris G, Avard Rachel C, Muniz de Queiroz Rafaela, Rustgi Anil K, Kaufman Laura J, Prives Carol
Abstract excerpt
Certain TP53 mutations can confer neomorphic gain of function (GOF) activities to the p53 protein that affect cancer progression. Yet the concept of mutant p53 GOF has been challenged. Here, using various strategies to alter the status of mutant versions of p53 in different cell lines, we demonstrate that mutant p53 stimulates cancer cell invasion in three-dimensional environments. Mechanistically, mutant p53...
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