Article
High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2007
Stoletov Konstantin, Montel Valerie, Lester Robin D, Gonias Steven L, Klemke Richard
Abstract excerpt
Cell metastasis is a highly dynamic process that occurs in multiple steps. Understanding this process has been limited by the inability to visualize tumor cell behavior in real time by using animal models. Here, we employ translucent zebrafish and high-resolution confocal microscopy to study how human cancer cells invade in tissues, induce angiogenesis, and interact with newly formed vessels. We use this system...
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