Article
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.
Allergy - 1 Jul 2011
Kezic S, O'Regan G M, Yau N, Sandilands A, Chen H, Campbell L E, Kroboth K, Watson R, Rowland M, McLean W H Irwin, Irvine A D
Abstract excerpt
BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA). Loss-offunction mutations in FLG lead to reduced levels of filaggrin degradation products in the SC. It has recently been suggested that expression of filaggrin may additionally be influenced by...
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