Article
Concentration of filaggrin monomers, its metabolites and corneocyte surface texture in individuals with a history of atopic dermatitis and controls.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 May 2018
Engebretsen K A, Bandier J, Kezic S, Riethmüller C, Heegaard N H H, Carlsen B C, Linneberg A, Johansen J D, Thyssen J P
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is characterized by skin barrier dysfunction. Notably, a high number of nano-scale protrusions on the surface of corneocytes, which can be expressed by the Dermal Texture Index (DTI), were recently associated with paediatric AD, loss-of-function mutations in filaggrin gene (FLG) and reduced levels of natural moisturizing factors (NMF). No study has so far examined the...
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