Article
Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis.
The Journal of allergy and clinical immunology - 1 Dec 2015
Riethmuller Christoph, McAleer Maeve A, Koppes Sjors A, Abdayem Rawad, Franz Jonas, Haftek Marek, Campbell Linda E, MacCallum Stephanie F, McLean W H Irwin, Irvine Alan D, Kezic Sanja
Abstract excerpt
BACKGROUND: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk factor for atopic dermatitis (AD) and are known to cause an epidermal barrier defect. The nature of this barrier defect is not fully understood. Patients with AD with FLG LOF mutations are known to have more persistent disease, more severe disease, and greater risk of food allergies and eczema herpeticum....
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