Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.

doi:10.1016/j.jdermsci.2022.04.007

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Article

Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.

Journal of dermatological science - 1 Jun 2022

Oláh Peter, Szlávicz Eszter, Kuchner Marcus, Nemmer Jana, Zeeuwen Patrick, Lefèvre-Utile Alain, Fyhrquist Nanna, Prast-Nielsen Stefanie, Skoog Tiina, Serra Angela, Rodríguez Elke, Raap Ulrike, Meller Stephan, Gyulai Rolland, Hupé Philippe, Kere Juha, Levi-Schaffer Francesca, Tsoka Sophia, Alexander Helen, Nestle Frank O, Schröder Jens M, Weidinger Stephan, van den Bogaard Ellen, Soumelis Vassili, Greco Dario, Barker Jonathan, Lauerma Antti, Ranki Annamari, Andersson Björn, Alenius Harri, Homey Bernhard

Abstract excerpt

BACKGROUND: Loss-of-function mutations in the filaggrin (FLG) gene directly alter skin barrier function and critically influence atopic inflammation. While skin barrier dysfunction, Th2-associated inflammation and bacterial dysbiosis are well-known characteristics of atopic dermatitis (AD), the mechanisms interconnecting genotype, transcriptome and microbiome remain largely elusive. OBJECTIVE: In-depth analysis...

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Identifiers

PMID: 35537882
DOI: 10.1016/j.jdermsci.2022.04.007

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