Article
Epidermal barrier dysfunction in atopic dermatitis.
The Journal of investigative dermatology - 1 Aug 2009
Cork Michael J, Danby Simon G, Vasilopoulos Yiannis, Hadgraft Jonathan, Lane Majella E, Moustafa Manar, Guy Richard H, Macgowan Alice L, Tazi-Ahnini Rachid, Ward Simon J
Abstract excerpt
Atopic dermatitis (AD) is a multifactorial, heterogenous disease that arises as a result of the interaction between both environmental and genetic factors. Changes in at least three groups of genes encoding structural proteins, epidermal proteases, and protease inhibitors predispose to a defective epidermal barrier and increase the risk of developing AD. Loss-of-function mutations found within the FLG gene...
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