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Article

Mouse Snail Is a Target Gene for HIF

22 Jan 2011

Abstract excerpt

The transcriptional inhibitor Snail is a critical regulator for epithelial-mesenchymal transition (EMT). Although low oxygen induces Snail transcription, thereby stimulating EMT, a direct role of hypoxia-inducible factor (HIF) in this process remains to be demonstrated. Here we show that hypoxia induces the expression of Snail via HIF. In silico analysis identified a potential hypoxia-response element (HRE) close...

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Identifiers

PMID: 21257819
DOI: 10.1158/1541-7786.mcr-10-0214

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