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Article

The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.

The Journal of biological chemistry - 5 Feb 2010

Viñas-Castells Rosa, Beltran Manuel, Valls Gabriela, Gómez Irene, García José Miguel, Montserrat-Sentís Bàrbara, Baulida Josep, Bonilla Félix, de Herreros Antonio García, Díaz Víctor M

Abstract excerpt

The transcription factor SNAIL1 is a master regulator of epithelial to mesenchymal transition. SNAIL1 is a very unstable protein, and its levels are regulated by the E3 ubiquitin ligase beta-TrCP1 that interacts with SNAIL1 upon its phosphorylation by GSK-3beta. Here we show that SNAIL1 polyubiquitylation and degradation may occur in conditions precluding SNAIL1 phosphorylation by GSK-3beta, suggesting that...

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Source

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Identifiers

PMID: 19955572
DOI: 10.1074/jbc.M109.065995
PMCID: PMC2823521

Genes

TWIST1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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