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Article

Direct regulation of TWIST by HIF-1alpha promotes metastasis.

Nature cell biology - 1 Mar 2008

Yang Muh-Hwa, Wu Min-Zu, Chiou Shih-Hwa, Chen Po-Min, Chang Shyue-Yih, Liu Chung-Ji, Teng Shu-Chun, Wu Kou-Juey

Abstract excerpt

Stabilization of the hypoxia-inducible factor-1alpha (HIF-1alpha) transcription complex, caused by intratumoural hypoxia, promotes tumour progression and metastasis, leading to treatment failure and mortality in different types of human cancers. The transcription factor TWIST is a master regulator of gastrulation and mesoderm-specification and was implicated recently as an essential mediator of cancer metastasis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18297062
DOI: 10.1038/ncb1691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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