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Article

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

15 Jul 2008

Abstract excerpt

Hypoxia is a microenvironmental factor which plays a critical role in development and tumor progression. The hypoxic response is mainly mediated by hypoxia inducible factor-1 (HIF-1) composed of HIF-1alpha and HIF-1beta, which becomes active under low oxygen condition. HIF-1 activates the transcription of hypoxia inducible genes which regulate diverse cellular functions including metabolism, angiogenesis and...

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PMID: 18635960
DOI: 10.4161/cc.7.14.6324

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