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Article

A gene regulatory network to control EMT programs in development and disease.

Nature communications - 11 Nov 2019

Fazilaty Hassan, Rago Luciano, Kass Youssef Khalil, Ocaña Oscar H, Garcia-Asencio Francisco, Arcas Aida, Galceran Juan, Nieto M Angela

Abstract excerpt

The Epithelial to Mesenchymal Transition (EMT) regulates cell plasticity during embryonic development and in disease. It is dynamically orchestrated by transcription factors (EMT-TFs), including Snail, Zeb, Twist and Prrx, all activated by TGF-β among other signals. Here we find that Snail1 and Prrx1, which respectively associate with gain or loss of stem-like properties and with bad or good prognosis in cancer...

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Source

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Identifiers

PMID: 31712603
DOI: 10.1038/s41467-019-13091-8
PMCID: PMC6848104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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