Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus.

Abstract excerpt

Lethal mutagenesis is an antiviral strategy that aims to extinguish viruses as a consequence of enhanced mutation rates during virus replication. The molecular mechanisms that underlie virus extinction by mutagenic nucleoside analogues are not well understood. When mutagenic agents and antiviral inhibitors are administered sequentially or in combination, interconnected and often conflicting selective constraints...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Foot-and-Mouth Disease
• Share to Foot-and-Mouth Disease Virus