Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient virus extinction by combinations of a mutagen and antiviral inhibitors.

Journal of virology - 1 Oct 2001

Pariente N, Sierra S, Lowenstein P R, Domingo E

Abstract excerpt

The effect of combinations of the mutagenic base analog 5-fluorouracil (FU) and the antiviral inhibitors guanidine hydrochloride (G) and heparin (H) on the infectivity of foot-and-mouth disease virus (FMDV) in cell culture has been investigated. Related FMDV clones differing up to 10(6)-fold in relative fitness in BHK-21 cells have been compared. Systematic extinction of intermediate fitness virus was attained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetinae
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

Share to Guanidine

Share to Heparin

Share to Mutagens

Share to Picornaviridae

Source

Open in PubMed Open full text

Identifiers

PMID: 11559805
DOI: 10.1128/JVI.75.20.9723-9730.2001
PMCID: PMC114544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient virus extinction by combinations of a mutagen and antiviral inhibitors.PMID 11559805Read ↗

Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus.Semantic proximity Read ↗

Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of InfectivitySemantic proximity Read ↗

Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus.Semantic proximity Read ↗

Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment.Semantic proximity Read ↗

Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction.Semantic proximity Read ↗

Quasispecies dynamics and RNA virus extinction.Semantic proximity Read ↗

Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections.Semantic proximity Read ↗

An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo.Semantic proximity Read ↗

Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load.Semantic proximity Read ↗

Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Semantic proximity Read ↗

A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.Semantic proximity Read ↗

Lethal mutagenesis of bacteria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.