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Article

Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections.

PLoS pathogens - 1 Nov 2009

Perales Celia, Agudo Rubén, Tejero Hector, Manrubia Susanna C, Domingo Esteban

Abstract excerpt

Lethal mutagenesis is an antiviral strategy consisting of virus extinction associated with enhanced mutagenesis. The use of non-mutagenic antiviral inhibitors has faced the problem of selection of inhibitor-resistant virus mutants. Quasispecies dynamics predicts, and clinical results have confirmed, that combination therapy has an advantage over monotherapy to delay or prevent selection of inhibitor-escape...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19911056
DOI: 10.1371/journal.ppat.1000658
PMCID: PMC2771356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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