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Article

Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection.

PloS one - 1 Jan 2012

Moreno Héctor, Tejero Héctor, de la Torre Juan Carlos, Domingo Esteban, Martín Verónica

Abstract excerpt

BACKGROUND: Lethal mutagenesis is a transition towards virus extinction mediated by enhanced mutation rates during viral genome replication, and it is currently under investigation as a potential new antiviral strategy. Viral load and virus fitness are known to influence virus extinction. Here we examine the effect or the multiplicity of infection (MOI) on progeny production of several RNA viruses under enhanced...

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Identifiers

PMID: 22442668
DOI: 10.1371/journal.pone.0032550
PMCID: PMC3307711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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