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Article

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.

Hepatology (Baltimore, Md.) - 1 Jan 2011

Stickel Felix, Buch Stephan, Lau Katharina, Meyer zu Schwabedissen Henriette, Berg Thomas, Ridinger Monika, Rietschel Marcella, Schafmayer Clemens, Braun Felix, Hinrichsen Holger, Günther Rainer, Arlt Alexander, Seeger Marcus, Müller Sebastian, Seitz Helmut Karl, Soyka Michael, Lerch Markus, Lammert Frank, Sarrazin Christoph, Kubitz Ralf, Häussinger Dieter, Hellerbrand Claus, Bröring Dieter, Schreiber Stefan, Kiefer Falk, Spanagel Rainer, Mann Karl, Datz Christian, Krawczak Michael, Wodarz Norbert, Völzke Henry, Hampe Jochen

Abstract excerpt

UNLABELLED: A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content. In addition, the PNPLA3 single-nucleotide polymorphism rs738409 (M148I) was reported to be associated with advanced alcoholic liver disease in alcohol-dependent individuals of Mestizo descent. We therefore evaluated the impact of rs738409 on the manifestation of alcoholic liver disease in two...

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Source

Identifiers

PMID: 21254164
DOI: 10.1002/hep.24017

Genes

PNPLA3

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.PMID 21254164Read ↗

Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.Semantic proximity Read ↗

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.Semantic proximity Read ↗

Variant in PNPLA3 is associated with alcoholic liver disease.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.Semantic proximity Read ↗

PNPLA3 rs738409 I748M is associated with steatohepatitis in 434 non-obese subjects with hepatitis C.Semantic proximity Read ↗

Association of single nucleotide polymorphism at PNPLA3 with fatty liver, steatohepatitis, and cirrhosis of liver.Semantic proximity Read ↗

Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males.Semantic proximity Read ↗

Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis CSemantic proximity Read ↗

The PNPLA3 rs738409 C > G polymorphism is associated with the risk of progression to cirrhosis in NAFLD patients.Semantic proximity Read ↗

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.Semantic proximity Read ↗

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

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