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Article

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.

Nature genetics - 1 Dec 2008

Romeo Stefano, Kozlitina Julia, Xing Chao, Pertsemlidis Alexander, Cox David, Pennacchio Len A, Boerwinkle Eric, Cohen Jonathan C, Hobbs Helen H

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups. To identify genetic variants contributing to differences in hepatic fat content, we carried out a genome-wide association scan of nonsynonymous sequence variations (n = 9,229) in a population comprising Hispanic, African American and European American individuals. An allele...

Read the complete abstract on PubMed

Topics

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Share to Fatty Liver
Share to PNPLA3 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

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Share to Lipid metabolism and disorders

Share to Liver Disease Diagnosis and Treatment

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Source

Open in PubMed Open full text

Identifiers

PMID: 18820647
DOI: 10.1038/ng.257
PMCID: PMC2597056

Genes

PNPLA3

Variants

rs738409
rs6006460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.PMID 18820647Read ↗

Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.Semantic proximity Read ↗

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PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.Semantic proximity Read ↗

Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype StudySemantic proximity Read ↗

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.Semantic proximity Read ↗

African genetic ancestry is associated with lower frequency of PNPLA3 G allele in non-alcoholic fatty liver in an admixed population.Semantic proximity Read ↗

Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphic (rs738409) single nucleotide polymorphisms and susceptibility to nonalcoholic fatty liver disease: A meta-analysis of twenty studies.Semantic proximity Read ↗

Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population.Semantic proximity Read ↗

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