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Article

Variant in PNPLA3 is associated with alcoholic liver disease.

Nature genetics - 1 Jan 2010

Tian Chao, Stokowski Renee P, Kershenobich David, Ballinger Dennis G, Hinds David A

Abstract excerpt

Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that r...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19946271
DOI: 10.1038/ng.488

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19946271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variant in PNPLA3 is associated with alcoholic liver disease.PMID 19946271Read ↗

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.Semantic proximity Read ↗

PNPLA3 in Alcohol-Related Liver Disease.Semantic proximity Read ↗

Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.Semantic proximity Read ↗

Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males.Semantic proximity Read ↗

Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis CSemantic proximity Read ↗

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.Semantic proximity Read ↗

The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohortSemantic proximity Read ↗

PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers.Semantic proximity Read ↗

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.Semantic proximity Read ↗

The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis.Semantic proximity Read ↗

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