PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.

doi:10.1038/ajg.2015.137

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Article

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.

The American journal of gastroenterology - 1 Jun 2015

Salameh Habeeb, Raff Evan, Erwin Angelika, Seth Devanshi, Nischalke Hans Dieter, Falleti Edmondo, Burza Maria Antonella, Leathert Julian, Romeo Stefano, Molinaro Antonio, Corradini Stefano Ginanni, Toniutto Pierluigi, Spengler Ulrich, Ulrich Spengler, Daly Ann, Day Christopher P, Kuo Yong-Fang, Singal Ashwani K

Abstract excerpt

OBJECTIVES: The genetic polymorphism with an isoleucine-to-methionine substitution at position 148 (rs738409 C>G) in the patatin-like phospholipase domain protein 3 (PNPLA3) gene confers risk of steatosis. PNPLA3 polymorphism is shown to be associated with alcoholic liver disease (ALD). We performed a systematic review and meta-analysis to examine association of this genetic polymorphism with ALD spectrum and its...

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PMID: 25964223
DOI: 10.1038/ajg.2015.137

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PNPLA3

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PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.PMID 25964223Read ↗

Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis.Semantic proximity Read ↗

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