Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.

doi:10.1016/j.jhep.2011.01.028

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Article

Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.

Journal of hepatology - 1 Oct 2011

Trépo Eric, Gustot Thierry, Degré Delphine, Lemmers Arnaud, Verset Laurine, Demetter Pieter, Ouziel Romy, Quertinmont Eric, Vercruysse Vincent, Amininejad Leila, Deltenre Pierre, Le Moine Olivier, Devière Jacques, Franchimont Denis, Moreno Christophe

Abstract excerpt

BACKGROUND & AIMS: A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis. This variant has also been linked to increased risk of alcoholic liver disease (ALD) and cirrhosis in Mestizo Mexicans with excessive alcohol intake. Our aim was to study the influence of this polymorphism on European Caucasian patients with...

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PMID: 21334404
DOI: 10.1016/j.jhep.2011.01.028

Genes

PNPLA3

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Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.PMID 21334404Read ↗

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.Semantic proximity Read ↗

PNPLA3 rs738409 I748M is associated with steatohepatitis in 434 non-obese subjects with hepatitis C.Semantic proximity Read ↗

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.Semantic proximity Read ↗

Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.Semantic proximity Read ↗

Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males.Semantic proximity Read ↗

PNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C.Semantic proximity Read ↗

PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.Semantic proximity Read ↗

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.Semantic proximity Read ↗

The PNPLA3 rs738409 C > G polymorphism is associated with the risk of progression to cirrhosis in NAFLD patients.Semantic proximity Read ↗

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.Semantic proximity Read ↗

Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis.Semantic proximity Read ↗

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