Article
Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males.
Hepatology international - 1 Sept 2018
Zhang Yanfang, Guo Tongsheng, Yang Funing, Mao Yuanli, Li Liubing, Liu Chenxi, Sun Qiang, Li Yongzhe, Huang Jing
Abstract excerpt
OBJECTIVE: Alcoholic liver disease (ALD) is a chronic liver disorder caused by the consumption of large amounts of alcohol. Genome-wide association studies have recently confirmed that polymorphisms in PNPLA3 predispose individuals to ALD and have identified risk loci of MBOAT7 and TM6SF2 in persons of European descent. However, the association with alcoholic liver damage has not been evaluated thus far in a Han...
Topics
- Adult
- Aged
- Asian People
- Case-Control Studies
- China
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lipase
- Liver Diseases, Alcoholic
- Logistic Models
- Male