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Article

Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C

12 Feb 2011

Abstract excerpt

Recent large-scale genetic studies in patients with chronic hepatitis C (CHC) provide evidence for a significant role of host genetic factors in its natural course [1], response to therapy [2], and incidence of therapy-related adverse effects [3]. Recently, a variant (rs738409 G>C) within the gene coding for patatin like phospholipase domain containing-3 (PNPLA3) was found associated with liver fat content and...

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PMID: 21316406
DOI: 10.1016/j.jhep.2011.01.025

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