Article
HID-1 is a novel player in the regulation of neuropeptide sorting.
The Biochemical journal - 15 Mar 2011
Yu Yong, Wang Lifen, Jiu Yaming, Zhan Yi, Liu Lin, Xia Zhiping, Song Eli, Xu Pingyong, Xu Tao
Abstract excerpt
Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named HID-1 acts to prevent mis-sorting of peptide cargoes to lysosomes for degradation via a PtdIns3P-dependent trafficking pathway. Epistasis...
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