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Article

Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Mar 2004

Cai Tao, Fukushige Tetsunari, Notkins Abner L, Krause Michael

Abstract excerpt

IA-2 (insulinoma-associated protein 2), a major autoantigen in type 1 diabetes, is a receptor-tyrosine phosphatase-like protein associated with the membrane of secretory granules of neural and endocrine-specific cells. Loss of IA-2 activity in the mouse results in reduced insulin release and additional phenotypes, consistent with a general effect on neurosecretion and hormone release. To gain further insight into...

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Identifiers

PMID: 15044551
DOI: 10.1523/JNEUROSCI.0101-04.2004
PMCID: PMC6729843

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CAPS

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